Asymmetric C–H Functionalization Enabled by Pd/Chiral Phosphoric Acid Combined Catalysis

Pu-Sheng Wang; Liu-Zhu Gong

doi:10.1055/a-1662-7096

Synthesis, Table of Contents

Synthesis 2022; 54(21): 4795-4801
DOI: 10.1055/a-1662-7096

special topic

Asymmetric C–H Functionalization

Asymmetric C–H Functionalization Enabled by Pd/Chiral Phosphoric Acid Combined Catalysis

Authors

Pu-Sheng Wang

^aHefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, P. R. of China
Liu-Zhu Gong∗

^aHefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, P. R. of China

^bCenter for Excellence in Molecular Synthesis of Chinese Academy of Sciences, Hefei 230026, P. R. of China

Abstract

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Abstract

Over the past decade, the combination of chiral phosphoric acid and palladium catalysis has emerged as a robust strategy to accomplish the regio- and stereoselective functionalization of inactive C–H bonds, enabling access to various types of chirality (central, planar, and axial). This review article describes the origin and advances in the asymmetric functionalization of allylic C–H, C(sp²)–H, and C(sp³)–H bonds enabled by chiral phosphoric acid and palladium combined catalysis.

1 Introduction

2.1 Enantioselective Allylic C–H Functionalization

2.2 Enantioselective Non-allylic C(sp³)–H Functionalization

2.3 Enantioselective C(sp²)–H Functionalization

3 Conclusion

Key words

asymmetric catalysis - palladium catalysis - C–H activation - chiral phosphoric acid - combined catalysis

Full Text

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